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It functions as a highly specific inhibitor of an enzyme called NNMT (Nicotinamide N-methyltransferase)

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Why Frequency Matters: The Science of B12 To understand why a provider might recommend weekly injections for a while, it helps to understand Vitamin B12 itself

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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